Research & Innovation

Advancing Diagnostics for Patients with Neurological Disorders

Neurolign has developed a comprehensive battery of tests that are intended to reveal the overall pattern of abnormalities associated with various conditions. We are in the process of developing algorithms based on metrics to identify patients with a variety of disorders with significant unmet diagnostic needs.

Future Products & Concepts

Neurolign’s next-generation systems are designed to seamlessly capture and share high-fidelity eye movement data with medical professionals for interpretation.

Dx-200

Neurolign is continually improving Dx-100 hardware and plans to introduce a second-generation system. The Dx-200 is a head mounted goggle (HMI) with high-speed eye tracking system using a dual camera approach and a high-resolution display. Dx-200 will provide visual and auditory stimuli to patients through HMI and tracks. The device will seamlessly record and share eye movement data with medical professionals for interpretation.

Proposed System Features
Lightweight and comfortable
QCS 610 Based SoM, running Android IOT
Wireless Joystick (Option for wired)
Status Lights and Single Button on Outside
USB-C Port for DFU, and tethered usage
Single Display (HD)
Speakers for Auditory instructions
Photo diode to synchronize display to camera
Dual camera simultaneous capture at 250FPS (one per eye)
Mechanics to Align Camera with eyes (no hot mirrors)

Featured Research

Neurolign utilizes industry-leading eye-tracking technology and expertise in neuroscience to develop innovative products that aid in the diagnosis and monitoring of neurological injury and disease.

Neurolign has developed a comprehensive battery of oculomotor, vestibular, reaction time, and cognitive (OVRT-C) tests delivered via the Neurolign Dx-100, our high-resolution eye-tracking goggle set. Together, results of these tests can reveal the unique and quantifiable patterns of OVRT-C deficits characteristic of specific neurological injuries or diseases.

Our multimodal method of OVRT-C testing makes us uniquely positioned to develop adjunctive tools with which to diagnose and monitor a number of these conditions and potentially contribute to patient recovery. Below, we share results from recent studies that highlight the efficacy of our novel approach to help clinicians diagnose and treat patients.

Neurolign Dx-100

Diagnostics in Development

Neurolign is developing algorithms to identify patients with a variety of disorders with significant unmet diagnostic needs.

Featured Publications

Manuscripts

Events

American Academy of Neurology 2022 | Seattle, WA

  • Oculomotor, vestibular, reaction time, and cognitive assessment in vestibular migraine

American Balance Society 2020 | Scottsdale, AZ

  • Oculomotor, vestibular, reaction time and cognitive (OVRT-C) tests in recovered COVID-19 patients

Patents

Title
Patent Number
Direct drive high torque compact synchronous motor
7,119,471
Portable video oculography system with integral light stimulus
7,448,751
Portable video oculography with region of interest image processing
7,520,614
Dynamic visual vestibular acuity testing protocol
7,651,224
Portable high speed head mounted pupil dilation tracking system
7,665,845
Portable video oculography system
7,731,360
Portable video oculography system with integral calibration light
7,753,523
Portable modular video oculography system and video oculography system with head position sensor and video oculography system with animated eye display
7,866,818
Compact neuro-otologic, neuro-ophthalmologic testing device and dynamic visual acuity testing and desensitization platform
8,333,472
Quantitative, non-invasive, clinical diagnosis of traumatic brain injury
8,585,609
Method and apparatus for corrective secondary saccades analysis with video oculography system
8,764,193
Quantitative, non-invasive, clinical diagnosis of traumatic brain injury using vog device for neurologic testing
9,039,631
Quantitative, non-invasive, clinical diagnosis of traumatic brain injury using vog device for neurologic optokinetic testing
9,039,632
Method and associated apparatus for detecting minor traumatic brain injury
9,084,573
Integrated video and electro-oculography system
9,101,296
Method and apparatus for corrective secondary saccades analysis with video oculography system and method for objective diagnostics of internuclear opthalmopligia, ocular later pulsion, progressive supernuclear palsy and glissade eye movements
9,107,616
Method of measuring and analyzing ocular response in a subject using stable pupillary parameters with video oculography system
9,198,571
Method and apparatus for system synchronization in video oculography based neuro-otologic testing and evaluation
9,247,870
Method and apparatus for validating testing procedures in objective ophthalmic eye testing for eye evaluation applications requiring subject compliance with eye fixation to a visual target
9,301,675
Apparatus and method for computerized rotational head impulse test
10,542,927
Method of measuring and analyzing ocular response in a subject using stable pupillary parameters with video oculography system
9,596,986
Method of precision eye-tracing through use of iris edge based landmarks in eye geometry
9,655,515
Head mounted compact goggle based video oculography system with integral stimulus screen
9,723,981
Method and apparatus for corrective secondary saccades analysis with video oculography system
9,730,583
Method and apparatus for system synchronization in video oculography based neuro-otologic testing and evaluation
10,314,485
Noninvasive rapid screening of mild traumatic brain injury using combination of subject’s objective oculomotor, vestibular and reaction time test measures
10,398,309
Apparatus and method for computerized rotational head impulse test
10,542,927
Method and associated apparatus for detecting minor traumatic brain injury
10,743,808

A Quantum Shift in Brain Health and Wellness

Neurolign is on a mission to create a quantum shift in the clinical approach to neurodegenerative disease while simultaneously revolutionizing brain health and wellness.